Xenium Analyzer是一台高度自动化、高通量的组织原位分析技术平台，将单分子RNA检测功能与强大的光学元件、数据采集和解码技术相结合，能够以亚细胞分辨率在整张FF或FFPE组织切片上快速检测大量靶点的组织原位表达水平，并兼容于10x Genomics的分析工具和流程，可实现Xenium数据的整合分析及可视化展示，最终实现数百个目标RNA基因同时进行高灵敏度的原位检测，从而精准分析组织原位中各类细胞的基因表达模式。
Xenium的独特性能和优势：
• 强大而独特的化学方法：高质量数据，可信度高，噪音小，灵敏度高
• 灵活的原位靶向Panels：各类商业化靶向Panel针对各类组织，兼容半定制和全定制panel，使您能够研究最为关注的生物学问题
• 快速的运行时间和更大的分析面积：意味着您可以处理更多样品和更大的切片
• 强大且免费的线下分析解决方案：无需云计算要求，下机数据直接进行深入分析和可视化展示
• 兼容多种样本类型的非破坏性工作流程：您可以从新鲜冷冻和FFPE样本中获得宝贵数据，还可以在同一张切片上运行其他工作流程，如H&E染色和免疫荧光染色技术，让您获得更深入的洞察力
10X Genomics现已推出人类乳腺组织、肺组织、脑组织及多组织基因的panel，小鼠的脑组织和多组织基因panel。各panel可增加1~100 定制化基因，应用场景仍在不断拓展。新的Prime 5K泛组织和通路分析使研究人员通过对5000个基因进行超精确的单细胞空间成像，更好的理解复杂的生物现象，应用于肿瘤、免疫和神经科学等不同领域的研究。
The Xenium Analyzer instrument is designed for fully automated high-throughput analysis of cells in their tissue environment. Part of an end-to-end solution that includes pre-designed, validated panels and analysis tools for visualizing and studying spatial patterns of expression, the Xenium Analyzer is next-level in situ. Xenium may also be combined with single cell and spatial discovery techniques to bring greater resolution and enable a deeper look into gene expression patterns, helping researchers develop and refine hypotheses.
Xenium in situ analysis detects and preserves the cellular localization of hundreds of RNA targets directly in a tissue section without the need for conventional sequencing. the new Prime 5K Assays (Human/Mouse) offers high-plex pan tissue & pathways assays for a new level of exploration in pathways, biomarkers, ligand–receptor pairings, and cell–cell interactions. This provides researchers with a detailed map of gene expression patterns without sacrificing resolution or target number. It will aid research in many application areas, including:
• Oncology: Reveal the spatial features of heterogeneity in the tumor and immune microenvironment and identify biomarkers with potential therapeutic impact.
• Immunology: Characterize the immune system and spatial localizations in response to infectious disease, allergic inflammation and autoimmune disorders.
• Neuroscience: Uncover spatial expression patterns in complex neural tissues in response to disease and traumatic injury.
Today’s spatial biology is mapping in unprecedented detail the organization of cells within tissues. These maps, produced on the Xenium Analyzer, will allow researchers to navigate the genesis of human disease and the pathway to discovering therapies. Xenium will open the door to answering tough biological questions that were once out of reach.

Xenium亚细胞空间原位分析技术服务
Xenium in Situ Gene Expression Analyses Service. Prices vary depending on the specific assay. Please consult BioCRF staff for more details.

为获得最佳结果，请样本检测前通过电子邮件或电话联系BioCRF工作人员来共同定制您的检测方案。
For optimal results, please reach out to BioCRF staff via email or phone to request a consultation meeting for the planning and processing of your samples.